Abstract: The wireless communication system is up against various engineering challenges. For both the transmitted and the received data processing, fast-access memories with large capacity are required in experimentation systems with Multiple-Input & Multiple-Output technique. SDRAM is a kind of random access memory with large-capacity and high-speed, but many Microprogrammed Control Units or normal Digital Signal Processors cannot directly interface with SDRAM due to the differences between control signals. Based on FPGA(field programmable gate array), a design method of SDRAM controller with USB interface to computer is proposed. Large-capacity data access is implemented at high speed by the controller circuit, which is working effectively in our MIMO experimentation system.