Abstract: The research uses the network collaborative construction theory to construct a national scientific cooperation network during the COVID-19 epidemic period, aiming to describe the evolution patterns of scientific research cooperation and the impact on the cooperation during the epidemic period. From the perspective of the cooperation network, the research calculates the network features to investigate the evolution patterns of the scientific research cooperation network. The present work also calculates the national cooperation freshness to investigate the dynamic evolution of the cooperation center. Finally, the regression discontinuity design is used to estimate the impact of the epidemic on national scientific research cooperation. The results show that the outbreak of the epidemic strengthens the scientific research cooperation. Furthermore, China played an important role in the epidemic, especially in the early stage. Although the cooperation center has gradually shifted with the change of the affected areas, China is still an important collaborator. Finally, our work studies the cooperative behavior of countries during the epidemic through regression discontinuity design and finds that the epidemic has been promoting people's ability to cooperate in fighting against disasters.