Abstract: The mathematical model of virus propagation in the mobile peer-to-peer(MP2P) networks is proposed by applying Epidemiology. Based on the proposed model and using the special digital-analysis software Matlab, large-scale experiments are done so as to examine the effect of the MP2P-related parameters on virus propagation. The results of these experiments illustrate that different parameters have different effects on virus propagation, among which the average downloading rate and the average recovery rate of fixed peers have the strongest effects on virus propagation.