Volume 44 Issue 1
Jun.  2017
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Article Navigation >  Journal of University of Electronic Science and Technology of China  > 2015  >  44(1): 155-160

WANG Jun, ZHOU Jie, XU Ying-ke, WANG Kang-kai, WANG Jü, LIU Yong, LIU Qing-jun, WANG Ping. Micro-Fabricated Electrochemical Insulin Sensor Modified with RuOx Nano Particles[J]. Journal of University of Electronic Science and Technology of China, 2015, 44(1): 155-160. doi: 10.3969/j.issn.1001-0548.2015.01.027
Citation: WANG Jun, ZHOU Jie, XU Ying-ke, WANG Kang-kai, WANG Jü, LIU Yong, LIU Qing-jun, WANG Ping. Micro-Fabricated Electrochemical Insulin Sensor Modified with RuOx Nano Particles[J]. Journal of University of Electronic Science and Technology of China, 2015, 44(1): 155-160. doi: 10.3969/j.issn.1001-0548.2015.01.027
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Micro-Fabricated Electrochemical Insulin Sensor Modified with RuOx Nano Particles

doi: 10.3969/j.issn.1001-0548.2015.01.027
  • 1.

    Biosensor National Special Lab,Zhejiang University Hangzhou 310027;

  • 2.

    State Key Lab of Silicon Materials,Zhejiang University Hangzhou 310027

  • Received Date: 2013-12-10
  • Rev Recd Date: 2014-09-22
  • Publish Date: 2015-02-15
  • Insulin detection is significant in clinical study, but the lack of effective detection methods impedes its clinical applications. In this work, the carbon microelectrode fabricated with MEMS (micro-electromechanical system) and C-MEMS (complex micro-electromechanical system) technology is applied for insulin detection. The carbon microelectrodes were fabricated through the pyrolysis of photoresist and showed good electrochemical performance. After electro-deposition of ruthinium oxide nano particles on the electrode surface, the insulin oxidation is electro-catalyzed and its electrochemical detection is realized at 0.7 V. The sensor has a sensitivity of 1 nA/μM for insulin detection, with a detection limit of 800 nM. Electrochemical measurement shows that the sensor has advantages of high sensitivity, fast response and usability for real time on-site detection.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Micro-Fabricated Electrochemical Insulin Sensor Modified with RuOx Nano Particles

doi: 10.3969/j.issn.1001-0548.2015.01.027
  • 1. Biosensor National Special Lab,Zhejiang University Hangzhou 310027;
  • 2. State Key Lab of Silicon Materials,Zhejiang University Hangzhou 310027
  • Received Date: 2013-12-10
  • Rev Recd Date: 2014-09-22
  • Publish Date: 2015-02-15

Abstract: Insulin detection is significant in clinical study, but the lack of effective detection methods impedes its clinical applications. In this work, the carbon microelectrode fabricated with MEMS (micro-electromechanical system) and C-MEMS (complex micro-electromechanical system) technology is applied for insulin detection. The carbon microelectrodes were fabricated through the pyrolysis of photoresist and showed good electrochemical performance. After electro-deposition of ruthinium oxide nano particles on the electrode surface, the insulin oxidation is electro-catalyzed and its electrochemical detection is realized at 0.7 V. The sensor has a sensitivity of 1 nA/μM for insulin detection, with a detection limit of 800 nM. Electrochemical measurement shows that the sensor has advantages of high sensitivity, fast response and usability for real time on-site detection.

WANG Jun, ZHOU Jie, XU Ying-ke, WANG Kang-kai, WANG Jü, LIU Yong, LIU Qing-jun, WANG Ping. Micro-Fabricated Electrochemical Insulin Sensor Modified with RuOx Nano Particles[J]. Journal of University of Electronic Science and Technology of China, 2015, 44(1): 155-160. doi: 10.3969/j.issn.1001-0548.2015.01.027
Citation: WANG Jun, ZHOU Jie, XU Ying-ke, WANG Kang-kai, WANG Jü, LIU Yong, LIU Qing-jun, WANG Ping. Micro-Fabricated Electrochemical Insulin Sensor Modified with RuOx Nano Particles[J]. Journal of University of Electronic Science and Technology of China, 2015, 44(1): 155-160. doi: 10.3969/j.issn.1001-0548.2015.01.027
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