Abstract: This article collected the information on family cluster confirmed cases of COVID-19 from Shenzhen Municipal Health Commission as an example. The first and second generations cases were identified according to the time of symptoms onset. Comparing the theoretical value of the second-generation cases calculated by the numerical model and the family structural network model with the actual value, the article found that the proportion of the second-generation cases in family cluster cases of females were significantly higher than that of males. The quantitative results support the hypothesis that women play the major part of the nursing role at home, and statically suggest that women were in higher susceptibility than men while implementing home quarantine as the main epidemic control measurement. Based on the current situation, the article listed out some advices to reduce the infection risk of women at the end.