Abstract: Oral squamous cell carcinoma (OSCC) is a malignant tumor idiopathic in the oral cavity, which is the most malignant and most harmful tumor of head and neck. The occurrence and development of oral squamous cell carcinoma is very heterogeneous, caused by the interaction between heredity and environment, including personalized lifestyles. To understand the complex mechanisms of OSCC at the systems biological level, there is an urgent need for a OSCC genetic variation database. In this research, the OSCC genetic variation database (GVDoscc) was established by both natural language processing and manually curating of data from PubMed. GVDoscc contains 1020 genetic variations and 608 clinical sample records extracted from 334 original articles, providing a reliable and accurate open-source for OSCC associated genetic variation pattern identification and molecular mechanism investigation.