Abstract: Attention deficit hyperactivity disorder (ADHD) is one of the most common mental disorders that develop in children. In this paper, a telemedicine system for ADHD based on multi-agent has been designed and implemented. A framework and collaborative model of multi-agent for telemedicine has been proposed. A evaluation system of multi-parameters based on multi-agent has been developed. Analytic hierarchy process is used for the decision-making of cooperative medicine and for the evaluation of ADHD. The ADHD patients were treated using an EEG biofeedback instrument at their home. The efficiency of the evaluation and therapy of ADHD is improved by using the telemedicine system.