Abstract: In order to inherit the traditional TV denoising algorithm of image edge protection, meanwhile, make up for inadequate noise suppression in the smooth area, this paper proposes a new denoising algorithm based on TV numerical calculation by using the spatial gradient and pixel gradient. An analysis is given to the spatial gradient of image, noise suppression of image smooth area, the inhibiting of spatial gradient in the region of interest and the iteration function of TV denoising based on pixel gradient. Experimental results show that the algorithm realizes edge-protection and less residual noise, and improves image peak signal to noise ratio and visual effects.