Abstract: Aiming at the problem of network structure influence on the control strategy on delaying the spatial spread of epidemic, the dual-population structure, hub structure, one-dimensional linear structure, and path superposition structure existing in the composite population network are studied, and the effects of patient isolation strategy and air traffic control strategy on delaying the first time of epidemic are analyzed, and the simulation verification is carried out through the American Airlines network. The results show that in the early stage of the outbreak, the control effect of timely patient isolation strategy is better than that of air traffic control strategy. The length of the epidemiological transmission structure is an important factor affecting the time of first arrival; The path overlay structure hardly affects the control effect of air traffic control strategy, but to a large extent, it inhibits the control effect of patient isolation strategy.