Abstract: A multi-channel micro-current digital readout system, comprising a data acquisition circuit and host computer software, was developed for the beam profile monitor in the beam diagnosis system of the Lanzhou Heavy Ion Cancer Treatment Facility. The data acquisition circuit is based on the current digital conversion chip ADAS1128, which has 256 analog input channels to receive the micro-current signals output from the split-strip ionization chamber detector and convert them into digital signals. The collected data is processed by FPGA and transmitted to the host computer by Gigabit Ethernet, and then received by the host computer software for storage, processing and display. The data acquisition circuit measures only 14 cm × 12 cm, making it easy to integrate with the split-strip ionization chamber detector. The test results indicate that within the operating range of 43.5 nA to 691.25 nA, the maximum channel noise is 3.8 nA, the non-linear error is less than 0.3%, and the maximum power consumption of a single channel in the system is approximately 13 mW. The system has proven to be stable and reliable after an extended period of operation. It can meet the requirements for high precision, high integration, and low power consumption in the data acquisition system of the split-strip ionization chamber detector.