Abstract: Based on the two-way time transfers, this paper presents a method processing contrast value that adopts a quasi-polynomial formed by least square estimation, in order to obtain the varying law of the clock difference between satellite and ground station because of the relative move between satellite and ground. Then the accurate clock difference when the satellite is over the top of ground station can be obtained through the differential of the polynomial, thereby the synchronization of satellite clocks is realized. This method may be applied to MEO satellite navigation and position system.