Abstract: Amlodipine maleate is a new kind of medicine for hypertensive disease. This article mainly studies the conditions of quantitatively measuring amlodipine maleate of tablet. The double-wave, 365 nm and 425 nm, spectrophotometry was used for determining the content of the amlodipine maleate tablet to eliminate interference of excipient. The absorbance is well linear with concentration between 5.0 μg/ml and 50.0 μg/ml, and the linear equation of differential spectrophotometry is △A=0.01149C+0.003 (r=0.9994), the coefficient of recovery is 99.92%, and RSD is 0.67%.