Abstract: Based on visual studio, this paper introduces a solution of PC-to-singlechip serial communication. It provides the modules of communication system in both PC and single chip, which are derived from the OSI network hierarchy module. This paper also provides the analysis of construction, data structure and scheduling of the modules. The hierarchy structure of this solution reflects the logical modularity of the whole system, whereby the system eliminates the reliability on hardware as much as possible. It provides the portability and flexibility to the system. The independence of each I/O driver on different hardware proves the coherence of subsystems.