富马酸二甲酯的合成研究

Study on Synthesis of Dimethyl Fumarate

  • 摘要: 简述了富马酸二甲酯的各种合成方法。详细研究了以对甲基苯磺酸和硫脲作为催化剂、以马来酸酐和甲醇作为原料合成富马酸二甲酯的反应条件,探讨了各种因素对合成反应的影响规律,得出了相应的最佳工艺条件,产品得率为92%。

     

    Abstract: This paper presents the many kinds of synthesis methods of Dimethyl Fumarate.The reation condition is investigated in detail with p-to-luenesulfonic acid,Thiourea as a catalysts and Maleic anhydride,Methanol as the reaction materials.The affection law of synthetic reaction is also discussed.Optimization technoloyical condition is obtained.The production yield reachs 92% with Thiourea 1.6 g,p-to-luenesulfonic acid 0.3 g,Malec anhydride 10.0 g,Methanol 20.0 g and reaction time 3 hours.

     

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