Abstract: A multi-sensor image fusion method based on redundant lifting non-separable wavelet transform is presented. This method can capture the detail information of an image accurately. The wavelet coefficients of the approximant and detail sub-images are fused respectively based-on the fusion rule of local area gradient. This method is effectively used to fuse the multi-spectral infrared images and the multi-sensor medical images. The results show that the proposed method has the property of shift-invariance and betterfusion effect.