Abstract: The Swiss National Science Foundation (SNSF) is the leading supporter of research funding in Switzerland and is primarily responsible for promoting the development of Swiss scientific and technological innovations. Therefore, it is necessary to explore the research status and research trends of the innovations according to SNSF data, which could inspire forward thinking of Chinese researchers and managers. We collected the data of research projects from the SNSF database in 1999−2018. In this study, the evolution of keywords in the information technology discipline is analyzed and it is found that information technology evolved from software development research, such as distributed systems to artificial intelligence research like machine learning and deep learning and hierarchical structure distribution maps, to visualize information technology and mathematical keyword distribution. It is worth noting that cryptography and algorithms are the most obvious cross-disciplinary research content in information technology and mathematics. The results show that research content of cross-disciplinary research is relatively better. Then, by interpreting the intersection of information technology and mathematics by Kullback-Leibler (KL) divergence analysis of keyword distribution in different time periods, the cross-research experience of these two disciplines is found that after rapid development, it entered a more stable and mature state.