Abstract: Methamphetamine is a new drug that can cause brain disfunction and even death. Most of the current studies only conducted enterprise resource planing (ERP) analysis on the electroencephalogram (EEG) signals of methamphetamine addicts, and rarely classified the EEG signals of methamphetamine addicts. This study conducted an ERP analysis on the EEG signals of two types of subjects, and then extracted to the time domain, frequency domain and wavelet coefficients of the EEG signals within this range for each experiment. The classification accuracy can reach higher than 80%. In addition, 4 of the 5 electrodes with a classification accuracy of more than 75% were located in the frontal lobe, indicating that methamphetamine had the most severe impact on the frontal lobe compared to other brain regions. Therefore, the methamphetamine may mainly damage the brain's thinking and cognitive execution functions. The C3 electrode is projected mainly in the primary motor cortex region, methamphetamine may have an impact on the function of exercise execution of the methamphetamine addicts. The result provides some theory to further study on the effects of methamphetamine.