Abstract: High resolution electroencephalography (EEG) signals were collected in eleven healthy subjects to study differences of the alpha wave (8～13 Hz) between eyes-closed and eyes-open resting states. In these two states, the mean power of alpha wave over 128 channels was computed and analyzed. Furthermore, brain regions of the alpha power were localized using standardized low resolution electromagnetic tomography (sLORETA) analyses and the difference of the alpha power between the eyes-closed and the eyes-open states was tested by t test. Results show that the alpha wave power is obviously stronger in the eyes-closed state than in the eyes-open state with significant difference in frontal, parietal and occipital regions.