Abstract: In order to reduce the interference and improve the system performances, this paper utilizes the idea of orthogonal frequency division multiplexing (OFDM) with interleaved subcarrier-index modulation (OFDM-ISIM) into Generalized frequency division multiplexing (GFDM), which is referred as interleaved subcarrier-index modulation GFDM (ISIM-GFDM). In the ISIM-GFDM, the data are mapped by the interleaved subcarrier-index modulation in each ISIM-GFDM subsymbol, which can enlarge the average Euclidean distance of the received symbols and improve the error performance of the signal recovery in the receiver. Simulation results show that ISIM-GFDM outperforms GFDM and SIM-GFDM in wireless mobile communication channel in terms of bit error rate (BER).